Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody–associated vasculitis

de Groot, Kirsten; Rasmussen, Niels; A Bacon, P; Willem Cohen Tervaert, Jan; Feighery, Conleth; Gregorini, Gina; L. Gross, Wolfgang; Luqmani, Raashid; Jayne, David

doi:10.1002/art.21142

Public

Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody–associated vasculitis

Published in Arthritis & Rheumatism • Jul 28, 2005

Authors:

Kirsten de Groot

Niels Rasmussen

P A Bacon

Abstract

OBJECTIVE: Standard therapy for antineutrophil cytoplasmic antibody-associated systemic vasculitis (AASV) with cyclophosphamide (CYC) and prednisolone is limited by toxicity. This unblinded, prospective, randomized, controlled trial was undertaken to determine whether methotrexate (MTX) could replac...

Subject

Medicine

Prednisolone

Cyclophosphamide

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