A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells

M. Dillon, Stephanie; Agrawal, Anshu; E. Van Dyke, Thomas; E. Landreth, Gary; K. McCauley, Laurie; J. Koh, Amy; R. Maliszewski, Charles; Akira, Shizuo; Pulendran, Bali

doi:10.4049/jimmunol.172.8.4733

Public

A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells

Published in The Journal of Immunology • Apr 1, 2004

Authors:

Stephanie M. Dillon

Anshu Agrawal

Thomas E. Van Dyke

Abstract

The adaptive immune system can generate distinct classes of responses, but the mechanisms that determine this are poorly understood. In this study, we demonstrate that different Toll-like receptor (TLR) ligands induce distinct dendritic cell (DC) activation and immune responses in vivo. Thus, Escher...

Subject

Cell biology

Signal transduction

Kinase

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