Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

Haniffa, Muzlifah; Shin, Amanda; Bigley, Venetia; McGovern, Naomi; Teo, Pearline; See, Peter; Singh Wasan, Pavandip; Wang, Xiao-Nong; Malinarich, Frano; Malleret, Benoît; Larbi, Anis; W.W. Tan, Pearlie; Zhao, Helen; Poidinger, Michael; Pagan, Sarah; Cookson, Sharon; Dickinson, Rachel; Dimmick, Ian; F. Jarrett, Ruth; Rénia, Laurent; Kit Chung Tam, John; Song, Colin; E. Connolly, John; Kok Yen Chan, Jerry; J. Gehring, Adam; Bertoletti, Antonio; Collin, Matthew; Ginhoux, Florent

doi:10.1016/j.immuni.2012.04.012

Public

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

Published in Immunity • Jul 1, 2012

Authors:

Muzlifah Haniffa

Amanda Shin

Venetia Bigley

Abstract

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8(+) T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance i...

Subject

Biology

Homology (biology)

Cell biology

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