Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

Ariyasu, Hiroyuki; Takaya, Kazuhiko; Tagami, Tetsuya; Ogawa, Yoshihiro; Hosoda, Kiminori; Akamizu, Takashi; Suda, Michio; Koh, Toshikiyo; Natsui, Koshi; Toyooka, Shigetake; Shirakami, Gotaro; Usui, Takeshi; Shimatsu, Akira; Doi, Kentaro; Hosoda, Hiroshi; Kojima, Masayasu; Kangawa, Kenji; Nakao, Kazuwa

doi:10.1210/jcem.86.10.7885

Public

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

Published in The Journal of Clinical Endocrinology & Metabolism • Oct 1, 2001

Authors:

Hiroyuki Ariyasu

Kazuhiko Takaya

Tetsuya Tagami

Abstract

Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat stomach and is involved in a novel system for regulating GH release. Although previous studies in rodents suggest that ghrelin is also involved in energy homeostasis and that ghrelin secretion is influenced by feed...

Subject

Ghrelin

Internal medicine

Endocrinology

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