Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.

C Lu, S; Alvarez, L; Z Huang, Z; Chen, L; An, W; J Corrales, F; A Avila, M; Kanel, G; M Mato, J

doi:10.1073/pnas.091016398

Public

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.

Shared by NobleBlocks on May 8, 2001 • 12:00 AM UTC

Authors:

S C Lu

L Alvarez

Z Z Huang

Abstract

Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. Mature liver expresses MAT1A, whereas MAT2A is expressed in extra...

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