Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Gu, Yong; Kuida, Keisuke; Tsutsui, Hiroko; Ku, George; Hsiao, Kathy; A. Fleming, Mark; Hayashi, Nobuki; Higashino, Kazuya; Okamura, Haruki; Nakanishi, Kenji; Kurimoto, Masashi; Tanimoto, Tadao; A. Flavell, Richard; Sato, Vicki; W. Harding, Matthew; J. Livingston, David; S.-S. Su, Michael

doi:10.1126/science.275.5297.206

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Shared by NobleBlocks on Jan 10, 1997 • 12:00 AM UTC

Authors:

Yong Gu

Keisuke Kuida

Hiroko Tsutsui

Abstract

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-γ inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating...

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