Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Gu, Yong; Kuida, Keisuke; Tsutsui, Hiroko; Ku, George; Hsiao, Kathy; Fleming, Mark; Hayashi, Nobuki; Higashino, Kazuya; Okamura, Haruki; Nakanishi, Kenji; Kurimoto, Masashi; Tanimoto, Tadao; A. Flavell, Richard; L. Sato, Vicki; W. Harding, Matthew; J. Livingston, David; Su, Michael

doi:10.1126/science.275.5297.206

Public

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Published in Science • Jan 10, 1997

Authors:

Yong Gu

Keisuke Kuida

Hiroko Tsutsui

Abstract

The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and...

Subject

Proinflammatory cytokine

Lipopolysaccharide

Propionibacterium acnes

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