A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

C. Ferreira, Ricardo; Guo, Hui; Coulson, Richard; J. Smyth, Deborah; Ł. Pękalski, Marcin; S. Burren, Oliver; J. Cutler, Antony; D. Doecke, James; Flint, Shaun; McKinney, Eoin; Lyons, Paul; G. C. Smith, Kenneth; Achenbach, Peter; Beyerlein, Andreas; B. Dunger, David; Clayton, David; S. Wicker, Linda; A. Todd, John; Bonifacio, Ezio; Wallace, Chris; Ziegler, Anette‐G.

doi:10.2337/db13-1777

Public

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

Published in Diabetes • Feb 22, 2014

Authors:

Ricardo C. Ferreira

Hui Guo

Richard Coulson

Abstract

Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost nothing is known about events leading to this islet autoimmunity. Previous epidemiological and genetic data have associated viral infections and...

Subject

Autoimmunity

Immunology

Autoantibody

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