The Nuclear Receptors FXR and LX alpha Potential Targets for the Development of Drugs Affecting Lipid Metabolism and Neoplastic Diseases

J. Niesor, Eric; Flach, Jean; Lopes-Antoni, Isabelle; Perez, Anne; Bentzen, C.

doi:10.2174/1381612013398185

Public

The Nuclear Receptors FXR and LX alpha Potential Targets for the Development of Drugs Affecting Lipid Metabolism and Neoplastic Diseases

Published in Current Pharmaceutical Design • Mar 1, 2001

Authors:

Eric J. Niesor

Jean Flach

Isabelle Lopes-Antoni

Abstract

The orphan nuclear receptors FXR and LXRalpha have become challenging targets for the discovery of new therapeutic agents. Bile acids and hydroxysterol intermediates are the respective natural ligands of these two structurally and functionally closely related receptors. Both FXR and LXRalpha; are th...

Subject

Farnesoid X receptor

Chenodeoxycholic acid

Liver X receptor

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