Safety and Efficacy of High-Dose Intravenous Acyclovir in the Management of Neonatal Herpes Simplex Virus Infections

W. Kimberlin, David; Lin, Chin‐Yu; F. Jacobs, Richard; A. Powell, Dwight; Corey, Lawrence; C. Gruber, William; H. Rathore, Mobeen; S. Bradley, John; S. Diaz, Pamela; L. Kumar, Mary; M. Arvin, Ann; Gutierrez, Kathleen; Shelton, Mark; B. Weiner, Leonard; W. Sleasman, John; Murguı́a de Sierra, Teresa; Weller, S; Soong, Seng‐Jaw; Kiell, Jan; D. Lakeman, Fred; J. Whitley, Richard

doi:10.1542/peds.108.2.230

Public

Safety and Efficacy of High-Dose Intravenous Acyclovir in the Management of Neonatal Herpes Simplex Virus Infections

Published in PEDIATRICS • Aug 1, 2001

Authors:

David W. Kimberlin

Chin‐Yu Lin

Richard F. Jacobs

Abstract

OBJECTIVE: The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of neonatal herpes simplex virus (HSV) disease. In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of...

Subject

Medicine

Dose

Herpes simplex virus

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