Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2.

Veedamali S, Subramanian,; Jonathan S, Marchant,; Hamid M, Said,

doi:10.1152/ajpcell.00105.2006

Public

Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2.

Published in American journal of physiology. Cell physiology • Nov 1, 2006

Authors:

Subramanian, Veedamali S

Marchant, Jonathan S

Said, Hamid M

Abstract

The water-soluble micronutrient thiamine is required for normal tissue growth and development in humans. Thiamine is accumulated into cells through the activity of two cell surface thiamine transporters (hTHTR1 and hTHTR2), which are differentially targeted in polarized tissues. Mutational dysfuncti...

Subject

Amino Acid Sequence

Animals

Basal Ganglia Diseases

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