Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Hartiala, Jaana; J. Bennett, Brian; Wilson Tang, W.H.; Wang, Zeneng; F.R. Stewart, Alexandre; J. Roberts, Robert; McPherson, Ruth; J. Lusis, Aldons; L. Hazen, Stanley; Allayee, Hooman

doi:10.1161/atvbaha.114.303252

Public

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Published in Arteriosclerosis Thrombosis and Vascular Biology • Mar 28, 2014

Authors:

Jaana Hartiala

Brian J. Bennett

W.H. Wilson Tang

Abstract

OBJECTIVE: Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goal of this study...

Subject

Trimethylamine N-oxide

Biology

Locus (genetics)

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