Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, Andrea; Copani, Agata; Caraci, Filippo; Aronica, Eleonora; J. Rozemuller, Annemieke; Caruso, Alessandra; Storto, Marianna; Gaviraghi, Giovanni; C. Terstappen, Georg; Nicoletti, Ferdinando

doi:10.1523/jneurosci.1381-04.2004

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Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Shared by NobleBlocks on Jun 28, 2004 • 12:00 AM UTC

Authors:

Andrea Caricasole

Agata Copani

Filippo Caraci

Abstract

We used primary cultures of cortical neurons to examine the relationship between β-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of Alzheimer's brain. Exposure of the cultures to β-amyloid peptide (βAP) induced the expression of t...

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