Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

F. Shern, Jack; Chen, Li; Chmielecki, Juliann; S. Wei, Jun; Patidar, Rajesh; Rosenberg, Mara; Ambrogio, Lauren; Auclair, Daniel; Wang, Jianjun; Song, Young; Tolman, Catherine; Hurd, Laura; Liao, Hongling; Zhang, Shile; Bogen, Dominik; S. Brohl, Andrew; Sindiri, Sivasish; Catchpoole, Daniel; Badgett, Thomas; Getz, Gad; Mora, Jaume; R. Anderson, James; X. Skapek, Stephen; G. Barr, Frederic; Meyerson, Matthew; S. Hawkins, Douglas; Khan, Javed

doi:10.1158/2159-8290.cd-13-0639

Public

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

Published in Cancer Discovery • Jan 16, 2014

Authors:

Jack F. Shern

Li Chen

Juliann Chmielecki

Abstract

UNLABELLED: Despite gains in survival, outcomes for patients with metastatic or recurrent rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute, Children's Oncology Group, and Broad Institute, we performed whole-genome, whole-exome, and transcriptome sequencing to ...

Subject

Rhabdomyosarcoma

Fusion

Fusion gene

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