Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells

Saito, Hirohisa; Ebisawa, Motohiro; Tachimoto, Hiroshi; Shichijo, Michitaka; Fukagawa, Kazumi; Matsumoto, K.; Iíkura, Yoji; Awaji, Takeo; Tsujimoto, Gozo; Yanagida, M.; Uzumaki, Hiroya; Takahashi, Gen; Tsuji, Kazuhiro; Nakahata, Tatsutoshi

doi:10.4049/jimmunol.157.1.343

Public

Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells

Published in The Journal of Immunology • Jul 1, 1996

Authors:

Hirohisa Saito

Motohiro Ebisawa

Hiroshi Tachimoto

Abstract

To establish the method for generating a large number of mature human mast cells, we cultured cord blood mononuclear cells (CBMC) in several conditions in the presence of Steel factor (SF). Among several cytokines tested, IL-6 enhanced SF-dependent mast cell growth from purified CD34+ cells for more...

Subject

Histamine

Immunoglobulin E

Mast cell

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