Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

L. Ather, Jennifer; Ckless, Karina; Martin, Rebecca; L. Foley, Kathryn; T. Suratt, Benjamin; E. Boyson, Jonathan; A. Fitzgerald, Katherine; A. Flavell, Richard; C. Eisenbarth, Stephanie; E. Poynter, Matthew

doi:10.4049/jimmunol.1100500

Public

Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

Published in The Journal of Immunology • May 27, 2011

Authors:

Jennifer L. Ather

Karina Ckless

Rebecca Martin

Abstract

IL-1β is a cytokine critical to several inflammatory diseases in which pathogenic Th17 responses are implicated. Activation of the NLRP3 inflammasome by microbial and environmental stimuli can enable the caspase-1-dependent processing and secretion of IL-1β. The acute-phase protein serum amyloid A (...

Subject

Inflammasome

Serum amyloid A

Immunology

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