Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, Jan; Andressoo, Jaan‐Olle; de Wit, Jan; G. M. Huijmans, J.; B. Beems, Rudolph; van Steeg, Harry; Weeda, Geert; T. J. van der Horst, Gijsbertus; van Leeuwen, Wibeke; P. N. Themmen, Axel; Meradji, M.; H.J. Hoeijmakers, Jan

doi:10.1126/science.1070174

Public

Premature Aging in Mice Deficient in DNA Repair and Transcription

Published in Science • May 17, 2002

Authors:

Jan de Boer

Jaan‐Olle Andressoo

Jan de Wit

Abstract

One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in XPD, a gene encoding a DNA helicase that functions in both repair and transcription and that is mutated in ...

Subject

Premature aging

DNA repair

DNA damage

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