SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis

Put, Stéphanie; Schoonooghe, Steve; Devoogdt, Nick; Schurgers, Evelien; Avau, Anneleen; Mitera, Tania; D’Huyvetter, Matthias; De Baetselier, Patrick; Raes, Geert; Lahoutte, Tony; Matthys, Patrick

doi:10.2967/jnumed.112.111781

Public

SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis

Published in Journal of Nuclear Medicine • Feb 27, 2013

Authors:

Stéphanie Put

Steve Schoonooghe

Nick Devoogdt

Abstract

UNLABELLED: Rheumatoid arthritis (RA) is a chronic autoimmune disease occurring in approximately 1% of the worldwide population. The disease primarily affects the joints, where inflammatory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction. Currently, it is dif...

Subject

Bone marrow

Medicine

Macrophage

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