A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing

E. Kimmel, Stephen; French, Benjamin; E. Kasner, Scott; A. Johnson, Julie; L. Anderson, Jeffrey; F. Gage, Brian; Rosenberg, Yves; S. Eby, Charles; Madigan, Rosemary; B. McBane, Robert; Z. Abdel‐Rahman, Sherif; M. Stevens, Scott; H. Yale, Steven; R. Mohler, Emile; C. Fang, Margaret; Shah, Vinay; B. Horenstein, Richard; A. Limdi, Nita; A.S. Muldowney, James; Gujral, Jaspal; Delafontaine, Patrice; J. Desnick, Robert; L. Ortel, Thomas; H. Billett, Henny; C. Pendleton, Robert; L. Geller, Nancy; L. Halperin, Jonathan; Z. Goldhaber, Samuel; D. Caldwell, Michael; M. Califf, Robert; H. Ellenberg, Jonas

doi:10.1056/nejmoa1310669

Public

A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing

Published in New England Journal of Medicine • Nov 19, 2013

Authors:

Stephen E. Kimmel

Benjamin French

Scott E. Kasner

Abstract

BACKGROUND: The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results. METHODS: We randomly assigned 1015 patients to receive doses of warfarin during the first 5 days of thera...

Subject

Medicine

Dosing

Pharmacogenetics

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