The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

K. Davis, Beckley; Wen, Haitao; P.‐Y. Ting, Jenny

doi:10.1146/annurev-immunol-031210-101405

Public

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Published in Annual Review of Immunology • Mar 2, 2011

Authors:

Beckley K. Davis

Haitao Wen

Jenny P.‐Y. Ting

Abstract

Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-defici...

Subject

Inflammasome

Biology

Inflammation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!