Detection of Tumor <i>PIK3CA</i> Status in Metastatic Breast Cancer Using Peripheral Blood

J. Higgins, Michaela; Jelovac, Danijela; Barnathan, Evan; Blair, Brian; Slater, Shannon; Powers, Penny; Zorzi, Jane; C. Jeter, Stacie; R. Oliver, George; Fetting, John; Emens, Leisha; Riley, Carol; Stearns, Vered; Diehl, Frank; Angenendt, Philipp; Huang, Peng; Cope, Leslie; Argani, Pedram; M. Murphy, Kathleen; E. Bachman, Kurtis; Greshock, Joel; C. Wolff, Antonio; H. Park, Ben

doi:10.1158/1078-0432.ccr-11-2696

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Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

Shared by NobleBlocks on Jun 14, 2012 • 12:00 AM UTC

Authors:

Michaela J. Higgins

Danijela Jelovac

Evan Barnathan

Abstract

Abstract Purpose: We sought to evaluate the feasibility of detecting PIK3CA mutations in circulating tumor DNA (ctDNA) from plasma of patients with metastatic breast cancer using a novel technique called BEAMing. Experimental Design: In a retrospective analysis, 49 tumor and temporally matched plasm...

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