PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Beck, Carole; Boehler, Christian; Guirouilh‐Barbat, Josée; Bonnet, Marie-Elise; Illuzzi, Giuditta; Rondé, Philippe; Gauthier, Laurent; Magroun, Najat; Rajendran, Anbazhagan; S. López, Bernard; Scully, Ralph; D. Boussin, François; Schreiber, Valérie; Dantzer, Françoise

doi:10.1093/nar/gku174

Public

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Published in Nucleic Acids Research • Mar 5, 2014

Authors:

Carole Beck

Christian Boehler

Josée Guirouilh‐Barbat

Abstract

The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ). Because these pathways compete for the repair of...

Subject

Ku80

Non-homologous end joining

Ku70

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