Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England.
Published in Clinical and diagnostic laboratory immunology • Sep 1, 2003
Authors:,,
Nick Andrews
Ray Borrow
Elizabeth Miller
Abstract
Meningococcal C conjugate (MCC) vaccines were licensed on the basis of serological correlates of protection without efficacy data. The original correlate of protection was established by using a serum bactericidal antibody assay (SBA) with human complement (hSBA), with titers > or =4 predicting prot...
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