Validation of Serological Correlate of Protection for Meningococcal C Conjugate Vaccine by Using Efficacy Estimates from Postlicensure Surveillance in England

Andrews, Nick; Borrow, Ray; Miller, Elizabeth

doi:10.1128/cdli.10.5.780-786.2003

Public

Validation of Serological Correlate of Protection for Meningococcal C Conjugate Vaccine by Using Efficacy Estimates from Postlicensure Surveillance in England

Published in Clinical and Vaccine Immunology • Sep 1, 2003

Authors:

Nick Andrews

Ray Borrow

Elizabeth Miller

Abstract

Meningococcal C conjugate (MCC) vaccines were licensed on the basis of serological correlates of protection without efficacy data. The original correlate of protection was established by using a serum bactericidal antibody assay (SBA) with human complement (hSBA), with titers > or =4 predicting prot...

Subject

Serology

Conjugate

Virology

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