Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Jónsson, Thorlákur; Stefánsson, Hreinn; Steinberg, Stacy; Jónsdóttir, Ingileif; V. Jónsson, Pálmi; Snædal, Jón; Björnsson, Sigurbjörn; Huttenlocher, Johanna; I. Levey, Allan; J. Lah, James; Rujescu, Dan; Hampel, Harald; Giegling, Ina; A. Andreassen, Ole; Engedal, Knut; Ulstein, Ingun; Djurovic, Srdjan; A. Ibrahim‐Verbaas, Carla; Hofman, Albert; Arfan Ikram, M.; M. van Duijn, Cornelia; Þorsteinsdóttir, Unnur; Kong, Augustine; Stefánsson, Kāri

doi:10.1056/nejmoa1211103

Public

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Published in New England Journal of Medicine • Nov 14, 2012

Authors:

Thorlákur Jónsson

Hreinn Stefánsson

Stacy Steinberg

Abstract

BACKGROUND: Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found. METHODS: We obtained the genome sequences of 22...

Subject

TREM2

Odds ratio

Alzheimer's disease

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