Tumor-Infiltrating FOXP3 <sup>+</sup> T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Salama, Paul; Phillips, Michael; Grieu, Fabienne; J. Morris, M.; Zeps, Nikolajs; Joseph, David; Platell, Cameron; Iacopetta, Barry

doi:10.1200/jco.2008.18.7229

Public

Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Published in Journal of Clinical Oncology • Dec 8, 2008

Authors:

Paul Salama

Michael Phillips

Fabienne Grieu

Abstract

PURPOSE: To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities. PATIENTS AND METHODS: Tissue microarrays and immunohistochemistry were used to assess t...

Subject

FOXP3

Colorectal cancer

Medicine

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