The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Yi; Tchkonia, Tamar; Pirtskhalava, Tamar; C. Gower, Adam; Ding, Husheng; Giorgadze, Nino; K. Palmer, Allyson; Ikeno, Yuji; B. Hubbard, Gene; E. Lenburg, Marc; P. O’Hara, Steven; F. LaRusso, Nicholas; D. Miller, Jordan; M Roos, Carolyn; Verzosa, Grace; K. LeBrasseur, Nathan; D. Wren, Jonathan; N. Farr, Joshua; Khosla, Sundeep; B. Stout, Michael; J. McGowan, Sara; Fuhrmann‐Stroissnigg, Heike; U. Gurkar, Aditi; Zhao, Jing; Colangelo, Debora; Dorronsoro, Akaitz; Yuan Ling, Yuan; S. Barghouthy, Amira; C. Navarro, Diana; Sano, Tokio; D. Robbins, Paul; J. Niedernhofer, Laura; L. Kirkland, James

doi:10.1111/acel.12344

Public

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Published in Aging Cell • Mar 9, 2015

Authors:

Yi Zhu

Tamar Tchkonia

Tamar Pirtskhalava

Abstract

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation ...

Subject

Biology

Transcriptome

Heel

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