MicroRNA-140 plays dual roles in both cartilage development and homeostasis

Miyaki, Shigeru; Sato, Tempei; Inoue, Atsushi; Otsuki, Shuhei; Ito, Yoshiaki; Yokoyama, Shigetoshi; Kato, Yoshio; Takemoto, Fuko; Nakasa, Tomoyuki; Yamashita, Satoshi; Takada, Shuji; Lotz, Martin; Ueno-Kudo, Hiroe; Asahara, Hiroshi

doi:10.1101/gad.1915510

Public

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

Published in Genes & Development • May 13, 2010

Authors:

Shigeru Miyaki

Tempei Sato

Atsushi Inoue

Abstract

Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation, mediated by several proteinases, including Adamts-5. miR-140 is one of a very limited number of noncoding microRNAs (miRNAs) speci...

Subject

Cartilage

Biology

Cell biology

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