Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide

A. Willment, Janet; Lin, Hsi-Hsen; M. Reid, Delyth; R. Taylor, Philip; L. Williams, David; Y. C. Wong, Simon; Gordon, Siamon; D. Brown, Gordon

doi:10.4049/jimmunol.171.9.4569

Public

Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide

Published in The Journal of Immunology • Nov 1, 2003

Authors:

Janet A. Willment

Hsi-Hsen Lin

Delyth M. Reid

Abstract

Dectin-1 is the major macrophage receptor for beta-glucans and generates a proinflammatory response through the recognition of these carbohydrates on fungal pathogens. We have examined the effects of cytokines and other agents on the expression and functions of dectin-1 in both resident and elicited...

Subject

Proinflammatory cytokine

Lipopolysaccharide

Zymosan

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