CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.

B, He; X, Qiao; A, Cerutti

doi:10.4049/jimmunol.173.7.4479

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CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.

Shared by NobleBlocks on Oct 1, 2004 • 12:00 AM UTC

Authors:

He B

Qiao X

Cerutti A

Abstract

TLRs are pattern recognition receptors that initiate innate immune responses. TLR9 detects microbial DNA with hypomethylated CpG motifs and in humans is preferentially expressed by IFN-alpha-producing plasmacytoid dendritic cells and B cells. In addition to favoring IFN-alpha release, TLR9 signals B...

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