Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults

Calderón‐Garcidueñas, Lilian; C. Solt, Anna; Henríquez‐Roldán, Carlos; Torres‐Jardón, Ricardo; Nuse, Bryan; Herritt, Lou; Villarreal‐Calderon, Rafael; Osnaya Brizuela, Norma; M. Stone, Ida; Garcı́a, Raquel; M. Brooks, Diane; González-Maciel, Angélica; Reynoso-Robles, Rafael; Delgado‐Chávez, Ricardo; Reed, William

doi:10.1177/0192623307313011

Public

Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults

Published in Toxicologic Pathology • Feb 1, 2008

Authors:

Lilian Calderón‐Garcidueñas

Anna C. Solt

Carlos Henríquez‐Roldán

Abstract

Air pollution is a serious environmental problem. We investigated whether residency in cities with high air pollution is associated with neuroinflammation/neurodegeneration in healthy children and young adults who died suddenly. We measured mRNA cyclooxygenase-2, interleukin-1beta, and CD14 in targe...

Subject

Neuroinflammation

Olfactory bulb

Oxidative stress

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