Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial.

AX, Zhu; M, Kudo; E, Assenat; S, Cattan; YK, Kang; HY, Lim; RT, Poon; JF, Blanc; A, Vogel; CL, Chen; E, Dorval; M, Peck-Radosavljevic; A, Santoro; B, Daniele; J, Furuse; A, Jappe; K, Perraud; O, Anak; DB, Sellami; LT, Chen

doi:10.1001/jama.2014.7189

Public

Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial.

Shared by NobleBlocks on Jul 1, 2014 • 12:00 AM UTC

Authors:

Zhu AX

Kudo M

Assenat E

Abstract

Importance Aside from the multikinase inhibitor sorafenib, there are no effective systemic therapies for the treatment of advanced hepatocellular carcinoma.Objective To assess the efficacy of everolimus in patients with advanced hepatocellular carcinoma for whom sorafenib treatment failed.Design, se...

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