Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication

Berger, Carola; Romero‐Brey, Inés; Radujković, Danijela; Terreux, Raphaël; Zayas, Margarita; Paul, David; Harak, Christian; Hoppe, Simone; Gao, Min; Pénin, François; Lohmann, Volker; Bartenschlager, Ralf

doi:10.1053/j.gastro.2014.07.019

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Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication

Published in Gastroenterology • Jul 18, 2014

Authors:

Carola Berger

Inés Romero‐Brey

Danijela Radujković

Abstract

BACKGROUND & AIMS: Direct-acting antivirals that target nonstructural protein 5A (NS5A), such as daclatasvir, have high potency against the hepatitis C virus (HCV). They are promising clinical candidates, yet little is known about their antiviral mechanisms. We investigated the mechanisms of daclata...

Subject

NS5A

Replication (statistics)

Virology

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