Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik‐Zainal, Serena; B. Alexandrov, Ludmil; C. Wedge, David; Van Loo, Peter; Greenman, Christopher; Raine, Keiran; Jones, David; Hinton, Jonathan; Marshall, John; Stebbings, Lucy; Menzies, Andrew; Martin, Sancha; Leung, Kenric; Chen, Lina; Leroy, Catherine; Ramakrishna, Manasa; Rance, Richard; Wai Lau, King; Mudie, Laura; Varela, Ignacio; J. McBride, David; R. Bignell, Graham; L. Cooke, Susanna; Shlien, Adam; Gamble, John; Whitmore, Ian; Maddison, Mark; Tarpey, Patrick; Davies, Helen; Papaemmanuil, Elli; J. Stephens, Philip; McLaren, Stuart; P. Butler, Adam; W. Teague, Jon; Jönsson, Göran; E. Garber, Judy; P. Silver, Daniel; Miron, Penelope; Fatima, Aquila; Boyault, Sandrine; Langerød, Anita; Tutt, Andrew; W.M. Martens, John; Aparício, Samuel; Borg, Åke; Vincent Salomon, Anne; Thomas, Gilles; Børresen‐Dale, Anne‐Lise; L. Richardson, Andrea; S. Neuberger, Michael; Andrew Futreal, P.; J. Campbell, Peter; R. Stratton, Michael

doi:10.1016/j.cell.2012.04.024

Public

Mutational Processes Molding the Genomes of 21 Breast Cancers

Published in Cell • May 1, 2012

Authors:

Serena Nik‐Zainal

Ludmil B. Alexandrov

David C. Wedge

Abstract

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied ...

Subject

Biology

Genome

Breast cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!