Comparison of analyses of urinary 8-hydroxy-2'-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay.

CW, Hu; MT, Wu; MR, Chao; CH, Pan; CJ, Wang; JA, Swenberg; KY, Wu

doi:10.1002/rcm.1367

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Comparison of analyses of urinary 8-hydroxy-2'-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay.

Shared by NobleBlocks on Jan 1, 2004 • 12:00 AM UTC

Authors:

Hu CW

Wu MT

Chao MR

Abstract

A highly sensitive and selective method, using isotope-dilution liquid chromatography with tandem mass spectrometry (LC/MS/MS), for quantification of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an important biomarker of oxidative stress, was developed and compared with a method using an enzyme-lin...

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