Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

Sulaiman, M.; J. Matta, M.; R. Sunderesan, N.; P. Gupta, M.; Periasamy, M.; Gupta, M.

doi:10.1152/ajpheart.00418.2009

Public

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

Shared by NobleBlocks on Mar 1, 2010 • 12:00 AM UTC

Authors:

M. Sulaiman

M. J. Matta

N. R. Sunderesan

Abstract

Reduced sarcoplasmic calcium ATPase (SERCA2a) expression has been shown to play a significant role in the cardiac dysfunction in diabetic cardiomyopathy. The mechanism of SERCA2a repression is, however, not known. This study was designed to examine the effect of resveratrol (RSV), a potent activator...

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