HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

E. Teschendorff, Andrew; Lee, Shih‐Han; Jones, Allison; Fiegl, Heidi; Kalwa, Marie; Wagner, Wolfgang; Chindera, Kantaraja; Evans, Iona; Dubeau, Louis; V. Orjalo, Arturo; M. Horlings, Hugo; Niederreiter, Lukas; Kaser, Arthur; Yang, Winnie; L. Goode, Ellen; L. Fridley, Brooke; G. Jenner, Richard; M.J.J. Berns, Els; Wik, Elisabeth; B. Salvesen, Helga; Bea A. Wisman, G.; G.J. van der Zee, Ate; Davidson, Ben; G. Tropé, Claes; Lambrechts, Sandrina; Vergote, Ignace; Calvert, Hilary; Jacobs, Ian; Widschwendter, Martin

doi:10.1186/s13073-015-0233-4

Public

HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

Published in Genome Medicine • Oct 24, 2015

Authors:

Andrew E. Teschendorff

Shih‐Han Lee

Allison Jones

Abstract

BACKGROUND: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients' lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of a cancer are integrally involved in pathways conferring chemo-resistance. Long ...

Subject

HOTAIR

Carboplatin

Ovarian cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!