Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins

M. O’Neill, Paul; K. Amewu, Richard; L. Nixon, Gemma; El Garah, Fatima; Mungthin, Mathirut; Chadwick, James; E. Shone, Alison; Vivas, Livia; Lander, Hollie; Barton, Victoria; Muangnoicharoen, Sant; G. Bray, Patrick; Davies, Jill; Kevin Park, B.; Wittlin, Sergio; Brun, Reto; Preschel, Michael; Zhang, Kesheng; A. Ward, Stephen

doi:10.1002/anie.201001026

Public

Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins

Published in Angewandte Chemie International Edition • Jul 13, 2010

Authors:

Paul M. O’Neill

Richard K. Amewu

Gemma L. Nixon

Abstract

Fighting drug resistence: From a library of over 150 1,2,4,5-tetraoxanes, the candidate RKA 182 was selected for preclinical development as an antimalarial agent. RKA 182 has outstanding in vitro activity against resistant strains of P. falciparum and retains this level of activity against southeast...

Subject

Artemisinin

Drug

Drug candidate

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