osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Bucay, Nathan; Sarosi, Ildiko; R. Dunstan, Colin; Morony, Sean; E Tarpley, J; Capparelli, C.; Scully, Sheila; Tan, Hong‐Lin; Xu, Weili; L. Lacey, David; J. Boyle, W.; Scott Simonet, W.

doi:10.1101/gad.12.9.1260

Public

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Published in Genes & Development • May 1, 1998

Authors:

Nathan Bucay

Ildiko Sarosi

Colin R. Dunstan

Abstract

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone...

Subject

Osteoprotegerin

Calcification

Internal medicine

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