Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

Tada, Kurisu; Okazaki, Tatsuma; Komazawa‐Sakon, Sachiko; Kobarai, Tomonari; Kurosawa, Kyoko; Yamaoka, Shoji; Hashimoto, Hiroshi; W. Mak, Tak; Yagita∥, Hideo; Okumura, Ko; Yeh, Wen‐Chen; Nakano, Hiroyasu

doi:10.1074/jbc.m104837200

Public

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

Published in Journal of Biological Chemistry • Sep 1, 2001

Authors:

Kurisu Tada

Tatsuma Okazaki

Sachiko Komazawa‐Sakon

Abstract

Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the TNF receptor superfamily. However, the exact roles of TRAF2 and TRAF5 in TNF-induced NF-kappaB activation still remain controversial. To address this issue, we generated TRAF2 and TRAF5 doub...

Subject

TRAF2

Tumor necrosis factor alpha

NF-κB

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