Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPARγ–Modulating Activity

C. Benson, Stephen; A. Pershadsingh, Harrihar; Ho, Christopher; G. Chittiboyina, Amar; Desai, Prashant; Pravenec, Michal; Qi, Nianning; Wang, Jiaming; A. Avery, Mitchell; W. Kurtz, Theodore

doi:10.1161/01.hyp.0000123072.34629.57

Public

Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPARγ–Modulating Activity

Published in Hypertension • Mar 9, 2004

Authors:

Stephen C. Benson

Harrihar A. Pershadsingh

Christopher Ho

Abstract

The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure. In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been rep...

Subject

Telmisartan

Endocrinology

Insulin resistance

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