Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Zhang, Li; Shimoji, Mika; Thomas, Bobby; J. Moore, Darren; Yu, Seong-Woon; I. Marupudi, Neena; Torp, Reidun; Aa. Torgner, Ingeborg; Petter Ottersen, Ole; M. Dawson, Ted; L. Dawson, Valina

doi:10.1093/hmg/ddi211

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Published in Human Molecular Genetics • Jun 8, 2005

Authors:

Li Zhang

Mika Shimoji

Bobby Thomas

Abstract

Both homozygous (L166P, M26I, deletion) and heterozygous mutations (D149A, A104T) in the DJ-1 gene have been identified in Parkinson's disease (PD) patients. The biochemical function and subcellular localization of DJ-1 protein have not been clarified. To date the localization of DJ-1 protein has la...

Subject

Biology

Subcellular localization

Mitochondrion

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