The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of <i>Prox1</i> expression in lymphatic endothelial cells

Sathish Srinivasan, R.; Geng, Xin; Yang, Ying; Wang, Yingdi; Mukatira, Suraj; Studer, Michèle; P.R. Porto, Marianna; V. Lagutin, Oleg; Oliver, Guillermo

doi:10.1101/gad.1859310

Public

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells

Published in Genes & Development • Apr 1, 2010

Authors:

R. Sathish Srinivasan

Xin Geng

Ying Yang

Abstract

The homeobox gene Prox1 is crucial for mammalian lymphatic vascular development. In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified. The maintenance of LEC identity also requires the constant expression of Prox1. However, the mechanisms controlling the expression of this g...

Subject

Biology

Nuclear receptor

Lymphatic system

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