<i>In vivo</i> multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

C. Skala, Melissa; M. Riching, Kristin; Gendron‐Fitzpatrick, Annette; C. Eickhoff, Jens; W. Eliceiri, Kevin; G. White, John; Ramanujam, Nirmala

doi:10.1073/pnas.0708425104

Public

In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

Published in Proceedings of the National Academy of Sciences • Nov 27, 2007

Authors:

Melissa C. Skala

Kristin M. Riching

Annette Gendron‐Fitzpatrick

Abstract

Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment of these metabolic electron carriers can be used to noninvasively monitor changes in metabolism, which is one of the hallmarks of carcinogenesis. This study combines cellular redox ratio, NADH and FAD lifetime...

Subject

Redox

Epithelium

Chemistry

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