Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies.

P, Guillon; M, Clément; V, Sébille; JG, Rivain; CF, Chou; N, Ruvoën-Clouet; Pendu J, Le

doi:10.1093/glycob/cwn093

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Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies.

Shared by NobleBlocks on Sep 25, 2008 • 12:00 AM UTC

Authors:

Guillon P

Clément M

Sébille V

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic emergent virus which replicates in cells that can express ABH histo-blood group antigens. The heavily glycosylated SARS-CoV spike (S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor. ...

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