HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

Gbadegesin, Rasheed; Adeyemo, Adebowale; J.A. Webb, Nicholas; A. Greenbaum, Larry; Abeyagunawardena, Asiri; Thalgahagoda, Shenal; S. Kale, Arundhati; S. Gipson, Debbie; Srivastava, Tarak; Lin, Jen-Jar; H. Chand, Deepa; E. Hunley, Tracy; D. Brophy, Patrick; Bagga, Arvind; Sinha, Aditi; N. Rheault, Michelle; R. Ghali, Joanna; Nicholls, Kathy; Abraham, Elizabeth; S. Janjua, Halima; Omoloja, Abiodun; Barletta, Gina-Marie; Cai, Yi; Milford, David; O′Brien, Catherine; Awan, Atif; Belostotsky, Vladimir; E. Smoyer, William; Homstad, Alison; Hall, Gentzon; Wu, Guanghong; Nagaraj, Shashi; R. Wigfall, Delbert; W. Foreman, John; P. Winn, Michelle

doi:10.1681/asn.2014030247

Public

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

Published in Journal of the American Society of Nephrology • Oct 28, 2014

Authors:

Rasheed Gbadegesin

Adebowale Adeyemo

Nicholas J.A. Webb

Abstract

Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array association study of SSNS. We enrolled a d...

Subject

Single-nucleotide polymorphism

Genetics

Exome

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