Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

D. Cani, Patrice; Bibiloni, Rodrigo; Knauf, Claude; Waget, Aurélie; M. Neyrinck, Audrey; M. Delzenne, Nathalie; Burcelin, Rémy

doi:10.2337/db07-1403

Public

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

Published in Diabetes • Feb 28, 2008

Authors:

Patrice D. Cani

Rodrigo Bibiloni

Claude Knauf

Abstract

OBJECTIVE: Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown. We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut microbiota and ...

Subject

Gut flora

Inflammation

Endocrinology

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