Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy<subtitle>A Randomized Clinical Trial</subtitle>

CONTEXT: Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. OBJECTIVE: To test the hypothesis of noninferiority between lactate clearance and central venous oxygen saturation (ScvO2) as goals of early sepsis ... View More