Contribution of hydrogen bonds to protein stability

Nick Pace, C.; Fu, Hailong; Lee Fryar, Katrina; D. Landua, John; Treviño, Saul; Schell, David; L. Thurlkill, Richard; Imura, Satoshi; Martin Scholtz, J.; Gajiwala, K.S.; Ševčı́k, Jozef; Urbanikova, L.; K. Myers, Jeffery; Takano, Kazufumi; J. Hebert, Eric; A. Shirley, Bret; R. Grimsley, Gerald

doi:10.1002/pro.2449

Public

Contribution of hydrogen bonds to protein stability

Published in Protein Science • Mar 3, 2014

Authors:

C. Nick Pace

Hailong Fu

Katrina Lee Fryar

Abstract

Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants in four proteins: villin headpiece subdomain (VHP) ...

Subject

Hydrogen bond

RNase P

Chemistry

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