Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, Masahiro; Sato, Shintaro; Hemmi, Hiroaki; Hoshino, Katsuaki; Kaisho, Tsuneyasu; Sanjo, Hideki; Takeuchi, Osamu; Sugiyama, Masanaka; Okabe, Masaru; Takeda, Kiyoshi; Akira, Shizuo

doi:10.1126/science.1087262

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Published in Science • Jul 14, 2003

Authors:

Masahiro Yamamoto

Shintaro Sato

Hiroaki Hemmi

Abstract

Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-beta production. Here we disrupted the gene encoding a Toll/IL-1 receptor ...

Subject

TRIF

TLR3

Signal transducing adaptor protein

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