Inferring tumour purity and stromal and immune cell admixture from expression data

Yoshihara, Kosuke; Shahmoradgoli, Maria; Martínez, Emmanuel; Vegesna, Rahulsimham; Kim, Hoon; Torres‐García, Wandaliz; Treviño, Víctor; Shen, Hui; W. Laird, Peter; A. Levine, Douglas; L. Carter, Scott; Getz, Gad; Stemke‐Hale, Katherine; B. Mills, Gordon; G.W. Verhaak, Roel

doi:10.1038/ncomms3612

Public

Inferring tumour purity and stromal and immune cell admixture from expression data

Published in Nature Communications • Oct 11, 2013

Authors:

Kosuke Yoshihara

Maria Shahmoradgoli

Emmanuel Martínez

Abstract

Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue and not only perturb the tumour signal in molecular studies but also have an important role in cancer biology. Here we describe ‘Estimation of STromal and Immune cells in MAlignant Tumours using Expression...

Subject

Stromal cell

Immune system

Computational biology

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