Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

L. Yu, Alice; L. Gilman, Andrew; Fevzi Özkaynak, M.; B. London, Wendy; G. Kreissman, Susan; X. Chen, Helen; A. Smith, Malcolm; Anderson, Barry; G. Villablanca, Judith; K. Matthay, Katherine; Shimada, Hiro; A. Grupp, Stephan; C. Seeger, Robert; Patrick Reynolds, C.; Buxton, Allen; A. Reisfeld, Ralph; D. Gillies, S.; L. Cohn, Susan; M. Maris, John; M. Sondel, Paul

doi:10.1056/nejmoa0911123

Public

Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

Published in New England Journal of Medicine • Sep 29, 2010

Authors:

Alice L. Yu

Andrew L. Gilman

M. Fevzi Özkaynak

Abstract

BACKGROUND: Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal antibody against the tumor-associated disialoganglioside GD2, has activity against neuroblastoma and that such activity is enhanced when ch14.18 is combined with granulocyte-macrophage colony-stimulating factor...

Subject

Medicine

Isotretinoin

Immunotherapy

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